The IndyMed Preparedness Initiative:
A roadmap from Corona, Long COVID, Post-Vac to Chronic Fatigue Syndrome and P4 Family Medicine

Nomenclature

AEFI

Adverse events following immunization

Aging

The process of becoming older, typically characterized by a decline in physical and sometimes mental capacities.

Aluminum salts

Commonly referred to as "alum," are adjuvants used in vaccines to enhance the body's immune response to an antigen.

Artificial Intelligence (AI)

The simulation of human intelligence processes by machines, especially computer systems.

Apo-E

Apolipoprotein E (Apo-E) plays a crucial role in the body's lipid metabolism. Apo-E binds Lipid Nanoparticles (LNPs) serving as delivery vehicles for targeting of mRNA vaccines.

Apo-E-Receptors

Apolipoprotein E (Apo-E) primarily binds to receptors within the low-density lipoprotein receptor (LDLR) family.

Babylonian Confusion

A metaphorical term referring to a state of confusion due to the overwhelming presence of diverse languages or terminologies.

CAR

Coxsackievirus and Adenovirus Receptor" (CAR) mediate the uptake of adenoviral vaccines, such as the vector vaccine of AstraZeneca.

CFS

Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis

ChatGPT

An AI language model developed by OpenAI, designed to understand and generate human-like text based on the input it receives.

Comirnaty

brand name for the COVID-19 mRNA vaccine developed by BioNTech/Pfizer.

Comorbidity

The simultaneous presence of two or more diseases or medical conditions in a patient.

Corona Statistics

Data and numerical analysis related to the coronavirus, including infection rates, mortality, and other epidemiological information.

Direct to Consumer (DTC) Gene Testing

Genetic tests that are marketed directly to consumers, allowing individuals to access information about their genetics without necessarily involving a healthcare provider.

EBV

Epstein-Barr virus causes infectious mononucleosis (kissing disease).

Electronic Health Record (EHR)

Digital version of a patient's paper chart, making information available instantly and securely to authorized users.

eQTL

Expression Quantitative Trait Loci, see Figure 3.

Exercise Physiology

Encompasses a wide range of topics, including how muscles, cardiovascular system, and respiratory system function during exercise with strong focus on the role of energy consumption in physical performance.

Extracellular Vesicles (EVs)

Small, membrane-bound particles released by cells into the extracellular environment. EVs carry a variety of molecular contents, including proteins, lipids, and nucleic acids assumed to influence the function and behavior of recipient cells.

Genome-Wide Association Studies (GWAS)

Studies that look for a correlation between specific genetic variants and particular diseases across many different people.

Host Genome Interaction

The study of interactions between the genetic makeup of an organism and external factors, like pathogens or environmental conditions.

IgG Trafficking

The process by which Immunoglobulin G (IgG) antibodies are transported across cell membranes, playing a critical role in immune response.

LDLR (low-density lipoprotein receptor)

LDL receptor-related protein (LRP1), and the very low-density lipoprotein receptor (VLDLR) are involved in the internalization and clearance of lipoprotein particles containing Apo-E from the bloodstream as wells Apo-E coated LNPs present in mRNA vaccines.

Legal Family Privacy

The right to privacy concerning the family unit and its members, often related to medical information or decisions.

Long-COVID

A range of symptoms that continue for weeks or months after the acute phase of a COVID-19 infection has resolved, such as fatigue, shortness of breath, loss of or altered sense of smell or taste, trouble thinking or focusing (often referred to as "brain fog"), chronic cough, headaches, difficulty sleeping, depression, anxiety, chest pain, heart palpitations, and diarrhea.

Longevity

The length of an individual's life, often studied in the context of factors that contribute to a longer lifespan.

LubecaVax

Home-made Corona protein vaccine by Dr. Stöcker.

Marathon Mice

The Dummerstorf high Treadmill Performance mouse line (DUhTP), selected for high treadmill performance over many generations, showed approximately 3.8 times higher running capacities compared to unselected controls.

Matrix-M

Matrix-M™ is a saponin derived from the bark of the Quillaja saponaria tree known to stimulate the immune response.

ME

Myalgic Encephalomyelitis, also known as Chronic Fatigue Syndrome (CFS).

ME/CFS

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (see below).

MHC allele Prediction

Predicting the specific variants of the Major Histocompatibility Complex (MHC) genes an individual possesses, important in immune system functioning.

MHC class I

Molecules found on the surface of all nucleated cells that present peptide fragments to immune cells, playing a critical role in immune response.

MHC class II

Molecules found on the surface of certain immune cells that present antigens to T cells, crucial in initiating immune responses.

Mitochondrial homeostasis

The balance and maintenance of optimal function and dynamics of mitochondria within a cell.

mRNA Vaccines

Vaccines that use a synthetic messenger RNA to instruct cells to produce a protein that is part of a pathogen, triggering an immune response.

Myalgic Encephalomyelitis-Chronic Fatigue Syndrome (ME/CFS)

A long-term illness with a wide range of symptoms, the most common of which is extreme tiredness broken down to exertional malaise, chronic fatigue that doesn't improve with rest, sleep problems, and cognitive impairments (often referred to as "brain fog").

Myokines

A group of cytokines or peptides produced and released by muscle fibers through contraction, being involved in metabolic regulation, inflammation, and muscle physiology.

Non-Pharmaceutical Intervention (NPI)

Actions, apart from getting vaccinated and taking medicine, that people and communities can take to help slow the spread of illnesses.

Nuvaxovid

Brand name for the COVID-19 protein vaccine developed by Novavax.

P4 Family Medicine

An approach to family medicine that is Predictive, Preventive, Personalized, and Participatory.

Participatory

Encourages patients to take an active role in their own healthcare, including decision-making and self-management.

Pandemic Preparedness Plan

A strategy or plan developed to prepare for and mitigate the effects of a pandemic.

Participatory

Encourages patients to take an active role in their own healthcare, including decision-making and self-management.

PASC

Post-Acute Sequelae of SARS-CoV-2 infection; often referred to as Long COVID.

PEM

Post-exertional malaise; a significant and debilitating symptom, particularly associated with Chronic Fatigue Syndrome (CFS).

Personalized

Tailoring healthcare to individual genetic, environmental, and lifestyle factors, ensuring treatments and preventions are more effective and less prone to adverse effects.

Predictive

This aspect involves using medical history, genetic testing, and other diagnostic tools to predict potential health issues before they occur.

Preventive

Focuses on preventing disease through measures like vaccinations, lifestyle changes, and early interventions based on predictive data.

Polygenic Disease Determination

The determination of a disease risk based on the presence or interaction of multiple genes.

Post-Vac

Referring to the time or conditions after vaccination.

Protein-Based Vaccine

Vaccines that use a harmless piece of a virus or bacteria to trigger an immune response.

PCRS

Polygenic Corona Risk Score, see Figure 3.

QPF

Qualitative protein functions, see Figure 3.

QRHG expression

Quantitative RNA host-gene expression, see Figure 3.

Public Health

The science and art of preventing disease, prolonging life, and promoting health through organized efforts and informed choices of society, organizations, public and private communities, and individuals.

ROS

Reactive Oxygen Species (ROS) perceived as harmful due to their role in oxidative stress and cell damage, ROS also play a crucial role in cell energy regulation and signaling.

SARS-CoV2

The virus responsible for COVID-19, a novel coronavirus identified at the end of 2019.

Single Nucleotide Polymorphism (SNP)

A variation at a single position in a DNA sequence among individuals, which can affect how humans develop diseases and respond to pathogens, chemicals, drugs, vaccines, and other agents.

Spikevax

Brand name for the COVID-19 mRNA vaccine developed by Moderna.

Social Media

Websites and applications that enable users to create and share content or participate in social networking.

Transgenerational Medicine

A branch of medicine that studies the health implications of the biological and environmental influences of an individual's parents and ancestors.

Vaccination

The administration of a vaccine to help the immune system develop protection from a disease.

Vaxzevira

Brand name for the COVID-19 vaccine developed by AstraZeneca and the University of Oxford.

VZV

Varicella zoster virus leads to chicken pox and Herpes Zoster (Shingles).